A GPCR Targeted By Small Molecules for The Treatment of Chronic Pain, Anxiety and Depression

Target Name: Nicotinic alpha9alpha10 Receptor

NCBI ID: P32821

Nicotinic alpha9alpha10 Receptor

Other Name(s): nAChR alpha9alpha10 receptor

A GPCR Targeted By Small Molecules for The Treatment of Chronic Pain, Anxiety and Depression

The Nicotinic alpha9alpha10 receptor (nAChR alpha9alpha10 receptor) is a G protein-coupled receptor (GPCR) that is expressed in various tissues throughout the body. It plays a crucial role in neural signaling and is involved in a wide range of physiological processes, including pain perception, anxiety, and mood regulation.

Recent studies have identified the nAChR alpha9alpha10 receptor as a potential drug target or biomarker for a variety of neurological and psychiatric disorders. By blocking the activity of this receptor, researchers can develop new treatments for conditions such as chronic pain, anxiety and depression.

The nAChR alpha9alpha10 receptor is a GPCR that is composed of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is responsible for the receptor's ability to interact with ligands, the transmembrane domain is responsible for the receptor's ability to transmit signals across the cell membrane, and the intracellular domain is responsible for the receptor's ability to interact with intracellular signaling molecules.

The nAChR alpha9alpha10 receptor is involved in a wide range of physiological processes, including pain perception, anxiety and mood regulation. Studies have shown that when the nAChR alpha9alpha10 receptor is activated, it can cause a variety of effects, such as increased pain sensitivity, anxiety and improved mood.

One of the key features of the nAChR alpha9alpha10 receptor is its sensitivity to small molecules, such as opioids and benzodiazepines. These molecules are often used to treat chronic pain, anxiety and depression. For example, opioids such as oxycodone and fentanyl have been shown to effectively block the nAChR alpha9alpha10 receptor.

Another potential mechanism by which the nAChR alpha9alpha10 receptor may be targeted by drugs is its role in the modulation of pain perception. Studies have shown that the nAChR alpha9alpha10 receptor is involved in the modulation of pain sensitivity and that its activation can cause an increase in pain perception. Therefore, blocking the activity of this receptor may be an effective way to alleviate pain.

Another potential mechanism by which the nAChR alpha9alpha10 receptor may be targeted by drugs is its role in the modulation of anxiety and mood. Studies have shown that the nAChR alpha9alpha10 receptor is involved in the modulation of anxiety and mood and that its activation can cause an increase in anxiety and depression-like behavior. Therefore, blocking the activity of this receptor may be an effective way to treat anxiety and depression.

The nAChR alpha9alpha10 receptor is also involved in the modulation of pain perception and anxiety and mood. Studies have shown that the nAChR alpha9alpha10 receptor is involved in the modulation of pain sensitivity and that its activation can cause an increase in pain perception. Therefore, blocking the activity of this receptor may be an effective way to alleviate pain.

In addition, the nAChR alpha9alpha10 receptor is also involved in the modulation of pain perception and anxiety and mood. Studies have shown that the nAChR alpha9alpha10 receptor is involved in the modulation of pain sensitivity and that its activation can cause an increase in pain perception. Therefore, blocking the activity of this receptor may be an effective way to alleviate pain.

The nAChR alpha9alpha10 receptor is also involved in the modulation of anxiety and mood. Studies have shown that the nAChR alpha9alpha10 receptor is involved in the modulation of anxiety and mood and that its activation can cause an increase in anxiety and depression-like behavior. Therefore, blocking

Protein Name: Nicotinic Alpha9alpha10 Receptor

The "Nicotinic alpha9alpha10 Receptor Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Nicotinic alpha9alpha10 Receptor comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets